Eli Lilly and Company plans a next-generation synthetic active pharmaceutical ingredient manufacturing facility on a 100-acre site in Huntsville, Alabama
U.S. manufacturing finished 2025 with strong momentum. In December, companies unveiled billions of dollars in new factory investments and expansions across the country, spanning pharmaceuticals, food and beverage, energy infrastructure, equipment, packaging, and advanced materials. Many of these projects are aimed at bringing production back onshore, reinforcing domestic supply chains, and creating thousands of skilled jobs. Below is a detailed look at the latest announcements, organized by sector and highlighting investment size, facility scope, employment impact, and direct statements from company leadership.
Pharmaceuticals & Biotechnology
Eli Lilly Invests Over $6 Billion in Huntsville API Facility (Alabama)
Eli Lilly and Company announced plans for a next-generation synthetic active pharmaceutical ingredient manufacturing facility on a 100-acre site in Huntsville, Alabama. The $6 billion project will support the production of small molecule and peptide medicines, including Lilly’s oral GLP‑1 candidate orforglipron, and is expected to create 450 high-value permanent jobs along with approximately 3,000 construction roles.
Lilly Chair and CEO David A. Ricks said the region’s track record in science and advanced manufacturing made Alabama an ideal choice: “Huntsville’s track record of science and innovation, supported by advanced manufacturing expertise and a skilled workforce, makes Alabama an ideal location for Lilly to expand domestic manufacturing capacity for next generation medicines,” he noted; the investment continues onshoring of API production and “strengthens supply chain resilience and reliable access to medicines for patients in the U.S.”
Novartis Breaks Ground on 700,000 sq ft Flagship Hub in North Carolina
Novartis began construction on a 700,000-square-foot manufacturing hub spanning Durham and Morrisville, North Carolina. The site is part of the company’s multibillion-dollar strategy to localize radioligand therapy manufacturing and is expected to generate approximately 700 new jobs.
CEO Vas Narasimhan highlighted the significance of the project’s launch: “This announcement is a commitment to American innovation and to the patients we serve… By building a full, end-to-end manufacturing presence in North Carolina, we are expanding our capacity to deliver medical breakthroughs.”
Samsung Biologics Acquires Its First U.S. Facility in Maryland
Samsung Biologics entered an agreement with GSK to acquire a 60,000-litre biologics manufacturing site in Rockville, Maryland, marking the company’s first production facility in the United States. The company plans additional investments to expand capacity at the site.
CEO John Rim described the acquisition as a milestone for the organization: “This landmark acquisition is a testament to our unwavering commitment to advancing global healthcare and bolstering our manufacturing capabilities in the U.S.”
TempraMed Opens U.S. Facility for Temperature-Controlled Medical Devices (Florida)
TempraMed, an Israeli health technology firm, opened a new manufacturing facility in Florida dedicated to producing temperature-controlled storage devices for biologic and GLP‑1 medications. The plant expands U.S. production capacity and supports the company’s collaboration with Eli Lilly.
CEO Ron Nagar said the new facility “marks a major step in strengthening our U.S. presence and ensuring we can meet the accelerating needs of healthcare providers, pharmacies, payors, and strategic partners.”
Anthro Energy Launches U.S. Electrolyte Manufacturing in Louisville (Kentucky)
Anthro Energy announced a $42.1 million investment to establish an advanced electrolyte manufacturing facility in Louisville, Kentucky. The plant will create 110 jobs and produce electrolyte materials for next-generation lithium-ion batteries, making it the first major U.S.-owned and operated facility of its kind.
Chief Technology Officer Joe Papp said, “We’re grateful to have earned the Department of Energy’s approval and are excited to begin scaling production of our advanced electrolytes here in Kentucky, becoming part of a community deeply committed to innovation and world-class manufacturing.”
Creative 3D Technologies Relocates Headquarters and Expands Production (Texas)
Creative 3D Technologies relocated its headquarters and expanded manufacturing operations to an 18,000-square-foot facility in Cedar Park, Texas. The site will function as the company’s research, development, and production hub, supporting approximately 45 high-skill jobs.
Founder and CEO Ethan Baehrend said the move positions the company for rapid growth: “Moving our headquarters and production operations in Cedar Park gives Creative 3D Technologies the ability to really sprint… Cedar Park’s hands-on support, the already well-established ecosystem with a diverse set of talent, and the physical facility we’re moving to allow us to accelerate production operations and bring some exciting new technology to the world.”
Food & Beverage
DrinkPAK Builds 1.4 Million sq ft Beverage Plant in Philadelphia (Pennsylvania)
DrinkPAK announced plans to construct a 1.4 million-square-foot beverage manufacturing facility at the former Philadelphia Energy Solutions site. The $195 million project is expected to create 174 direct jobs and significantly expand the company’s production footprint.
CEO Nate Patena said the new facility reinforces the company’s leadership position: “Our 1.4 million-square-foot Philadelphia location will continue to solidify DrinkPAK’s position as North America’s premier canned beverage manufacturer, with the ability to service our clients with any drink, any can, any format, and now, in any location.”
Swire Coca-Cola Selects Colorado Springs for $475 Million Plant (Colorado)
Swire Coca-Cola USA will break ground on a 620,000-square-foot bottling plant in Colorado Springs. The $475 million investment will create approximately 170 jobs and is targeting LEED Gold certification.
Senior Vice President of Supply Chain Bryan Sink said the region’s workforce and partnership made the city an ideal fit: “Colorado Springs has been a great partner for our existing distribution facility, where we employ 170 people. The city offers a highly skilled workforce and a strong sense of community—all of which make it an ideal location for this strategic investment.”
Pierce Manufacturing Invests Over $150 Million in Wisconsin Plants
Pierce Manufacturing, a subsidiary of Oshkosh Corporation, announced more than $150 million in upgrades across its Appleton, Wisconsin, facilities. The investments include advanced robotics and fabrication technologies designed to improve efficiency and safety.
Executive Vice President Mike Pack said the upgrades are already delivering results: “These technologies reflect our dedication to continuous improvement and safety, as well as our commitment to delivering fire apparatus to firehouses faster while maintaining the same exceptional level of quality that defines our products…We have already reduced lead times by over three months from their peak. With these sustained investments, we are continuing to work to return to pre-pandemic lead times.”
Energy & Infrastructure
LS Cable & System Commits $689 Million to Chesapeake Manufacturing Complex (Virginia)
LS Cable & System Ltd. will invest $689 million to build a manufacturing complex in Chesapeake, Virginia, producing copper rod, magnet wire, and rare earth magnets. The project will create more than 430 jobs and significantly expand the company’s U.S. manufacturing presence.
President and CEO Bon Kyu Koo said the investment strengthens domestic capabilities: “We’re not only expanding our manufacturing capabilities, but we’re also strengthening the U.S. domestic supply chains and supporting America’s leadership in energy and technology.”
Sanmina Builds Energy Equipment Factory in Houston (Texas)
Sanmina Corporation announced a major expansion of its energy business with a new manufacturing facility in Houston focused on medium- and high-voltage transformers and switchgear.
Chairman and CEO Jure Sola said the project aligns closely with Sanmina’s strengths: “We are very pleased to announce this expansion of Sanmina’s Energy-related business. We believe that the transmission, distribution and storage of electric power provides an excellent fit for Sanmina’s core competencies in engineering and manufacturing to deliver cutting-edge medium-voltage and high-voltage equipment.”
Industrial & Materials
Vollrath Company Starts $40 Million Expansion in Sheboygan (Wisconsin)
The Vollrath Company broke ground on a new 110,000-square-foot manufacturing facility at its Sheboygan headquarters. The project represents the first phase of a multi-year investment estimated at $40 million and will modernize production while consolidating operations.
CEO Erik Lampe said the expansion reflects a long-term commitment to the community: “After 150 years in Sheboygan, we are making this substantial investment because we believe in the future of this community and the exceptional workforce that calls it home. Our current facility, built in 1912, has served us well, but to remain competitive and continue growing, we need to invest in modern infrastructure that allows us to streamline how we work, stay at the cutting edge of manufacturing technology, and make it even easier for customers to do business with us.”
GZ PrintPak Establishes 69,000 sq ft Plant in Wisconsin
GZ PrintPak announced a $7.1 million investment to build a 69,000-square-foot manufacturing facility in Racine County, Wisconsin, producing recyclable luxury paper bags for North American customers.
Chairman Peter Levenec highlighted the advantages of the location: “We’re really proud to be here, because Wisconsin offers an ideal mix of workforce availability, infrastructure, and location advantages — enabling us to better serve our customers across North America.”
Coastal Ready Mix Establishes Ready Mix Concrete Plant (South Carolina)
Coastal Ready Mix is investing $4.6 million to build a new ready-mix concrete plant in Conway, South Carolina. The project will create 19 jobs and expand the family-owned company’s footprint in the region.
CEO Scott Askins said the expansion reflects both opportunity and gratitude: “We’re grateful for the opportunity to serve Horry County, and we give thanks to God for opening this door for our family. We try to work hard, do what’s right and take care of the people who depend on us. Expanding into this community is a blessing, and we look forward to earning the trust of the contractors and customers we serve.”
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Article Source: New U.S. Manufacturing Operations Announced in December 2025